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Cat#：211P28
序列（三字母）：Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH trifluoroacetate salt(Disulfide bonds between Cys3 and Cys3?/Cys12 and Cys2?/Cys1? and Cys32)
序列（單字母）：Fluorescein-6-carbonyl-AEEAc-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
類似名：6-FAM-AEEAc-ShK, ShK-F6CA
分子式：C???H???N??O??S?
分子量：4558.3
CAS#：1927927-42-1
合成方法：Synthetic
存儲條件：-20 ± 5 °C
應(yīng)用：Ion Channel Modulating Agents
描述：This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ?-amino group of Arg1, selectively blocked the voltage gated T-lymphocyte K? Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. It potently blocked Kv1.3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1.3 over Kv1.1 and other Kv channels. In flow cytometry experiments, chronically activated rat and human T-lympocytes with >600 Kv1.3 channels/cell were readily distinguished from resting and acutely activated T-lymphocytes with lower Kv1.3 channel numbers. 6-FAM-AEEAc-Stichodactyla helianthus neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues.