產品詳情
Cat#：159P05
序列（三字母）：H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt(Disulfide bonds between Cys? and Cys23/Cys1? and Cys13/Cys11 and Cys1?/Cys1? and Cys22)
序列（單字母）：DTHFPICIFCCGCCHRSKCGMCCKT
類似名：LEAP-1 (human), Hepc25 (human), Liver-Expressed Antimicrobial Peptide (human), PLTR (human), Putative Liver Tumor Regressor (human)
分子式：C???H???N??O??S?
分子量：2789.4
CAS#：1356390-47-0
合成方法：Synthetic
存儲條件：-20 ± 5 °C
應用：Antimicrobial & Antiviral Peptides|
Hematology
描述：Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity. Former CAS-number 342790-21-0.
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